Largest religious building built in Cape Verde and in the entire African coast. Built around 1556, when the Episcopal palace was also built, currently without apparent traces. Its construction was completed around 1700, being practically destroyed (as known today), following the last major attack perpetrated by the French privateer, Jacques Cassard, in 1712.

Built on the threshold of the 16th century, between 1512 and 1520, as a symbol of municipal power and royal justice. Located in the center of the city, it was the place where the acts of the City Council were publicly read, infractions were repressed and a privileged space for commercial exchanges, namely slaves and other products of the land.

Built in the late 15th century (1495), it first housed a Manueline-style chapel, later expanded into the body of the church of Our Lady of the Rosary. It is one of the oldest religious buildings still standing, and a rare example of Gothic architecture in sub-Saharan Africa. It was part of one of the most important ecclesiastical brotherhoods that existed in Ribeira Grande de Santiago, the Brotherhood of Our Lady of the Rosary.

The church of Nossa Senhora da Conceição, one of the oldest churches in Cape Verde, would have been built between 1466 and 1470, after the probable institution of small oratories, after the arrival of the first settlers in 1462, being the Infante D. Fernando responsible for its materialization. The church of N. ª S.ª da Conceição was the first to be built of stone and whitewash, and served as an oratory for the lordly inhabitants of the São Pedro district. It was preferred by the "morgados" in their pious donations.

Built around 1640, on a plot of land donated by Joana Coelho, a wealthy rural landowner, widow of Captain Fabião de Andrade. It was designed to accommodate the Franciscan religious who replaced the Jesuits in the mission in Cape Verde. It also functioned as a training center, where the priests taught various trades to the community. It was practically destroyed after the attack of the corsair Jacques Cassard in 1712 and a storm in 1754.

Rua da Banana is the oldest street built by the Portuguese in Sub-Saharan Africa and the tropics, the street consists of a set of simple single-plan houses built of stone and lime, with one door and two windows and roof of straw.

Parallel to this Rua Banana is Rua Carreira with identical construction typologies. In the sixteenth century there were 500 good residences of loss and whitewash in this city (according to an anonymous writing of the time).